Title:
シクロオキシゲナーゼ-2阻害剤の迅速崩壊経口製剤
Document Type and Number:
Japanese Patent JP2004506680
Kind Code:
A
Abstract:
A molded article such as a tablet is provided for administration to an oral cavity of a subject to treat or prevent a cyclooxygenase-2 mediated condition, disorder or disease. The molded article comprises a moldable blend of a therapeutically effective amount of a selective cyclooxygenase-2 inhibitory drug with a pharmaceutically acceptable excipient carrier system consisting predominantly of one or more carbohydrates, wherein ingredients and amounts thereof in the molded article and a process for preparing the molded article are selected such that the molded article exhibits rapid disintegration in the oral cavity, and wherein the moldable blend is prepared by a process step not requiring wet granulation.
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Inventors:
Carlari, Togular Tea
Contney, mark jay
Les, Trung Tea
Contney, mark jay
Les, Trung Tea
Application Number:
JP2002520806A
Publication Date:
March 04, 2004
Filing Date:
August 17, 2001
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
C07D237/04; A61K9/00; A61K9/20; A61K31/341; A61K31/352; A61K31/415; A61K31/42; A61K31/444; A61K31/451; A61K31/485; A61K31/50; A61K45/08; A61K47/10; A61K47/26; A61K47/36; A61K47/38; A61P11/06; A61P19/02; A61P29/00; C07D213/61; C07D231/12; C07D261/08; C07D307/58; C07D311/58; (IPC1-7): A61K45/08; A61K9/20; A61K31/341; A61K31/352; A61K31/415; A61K31/42; A61K31/444; A61K31/451; A61K31/485; A61K31/50; A61K47/10; A61K47/26; A61K47/36; A61K47/38; A61P11/06; A61P19/02; A61P29/00
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri