RATIONALLY DESIGNED SYNTHETIC ANTIBODY LIBRARIES AND USES THEREOF

Title:

RATIONALLY DESIGNED SYNTHETIC ANTIBODY LIBRARIES AND USES THEREOF

Document Type and Number:

Japanese Patent JP2015025015

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a rationally designed synthetic antibody libraries and uses thereof.SOLUTION: There is provided a procedure to overcome the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.

Inventors:

MAXIMILIANO VASQUEZ
MICHAEL FELDHAUS
GERNGROSS TILLMAN U
K DANE WITTRUP

Application Number:

JP2014220988A

Publication Date:

February 05, 2015

Filing Date:

October 30, 2014

Export Citation:

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Assignee:

ADIMAB INC

International Classes:

C40B40/08; C07K16/18; C12N1/19; C12N15/09

Foreign References:

US20060177440A1	2006-08-10
US20060177440A1	2006-08-10

Other References:

NAT. BUITECHNOL. (1996) VOL.14, NO.3, P.309-314, JPN6016037954
SCAND. J. IMMUNOL. (2000) VOL.51, ISSUE 4, P.337-344, JPN6016037955
J. BIOL. CHEM. (1999) VOL.274, NO.26, P.18218-18230, JPN6016037956
NAT. BUITECHNOL. (1996) VOL.14, NO.3, P.309-314, JPN6016037954
SCAND. J. IMMUNOL. (2000) VOL.51, ISSUE 4, P.337-344, JPN6016037955
J. BIOL. CHEM. (1999) VOL.274, NO.26, P.18218-18230, JPN6016037956

Attorney, Agent or Firm:

Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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