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Title:
REAGENT AND METHOD FOR ENGAGING UNIQUE CLONOTYPIC LYMPHOCYTE RECEPTOR
Document Type and Number:
Japanese Patent JP2012184233
Kind Code:
A
Abstract:

To induce and expand therapeutically useful numbers of specific lymphocyte populations by using platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor.

Antigen-presenting platforms comprising a T cell affecting molecule and an antigen-presenting complex can induce and expand antigen-specific T cells in the presence of relevant peptides, providing reproducible and economical methods for generating therapeutic numbers of such cells. Antibody-inducing platforms comprising a B cell affecting molecule and a molecular complex that engages MHC-antigen complexes on a B cell surface can be used to induce and expand B cells that produce antibodies with particular specificities.


Inventors:
SCHNECK JONATHAN
OELKE MATHIAS
Application Number:
JP2012092552A
Publication Date:
September 27, 2012
Filing Date:
April 16, 2012
Export Citation:
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Assignee:
UNIV JOHNS HOPKINS
International Classes:
C07K17/00; A61K35/14; A61K39/385; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P37/06; C07K7/06; C07K7/08; C07K14/47; C07K17/02; C12N5/00; C12N5/0781; C12N5/0783; G01N33/50; A61K35/12; A61K39/00; C07K14/52; C07K14/705; C07K14/74; C07K16/28
Domestic Patent References:
JPH11507843A1999-07-13
JP2001515726A2001-09-25
JPH11507843A1999-07-13
JPH10503379A1998-03-31
JP2001515726A2001-09-25
Other References:
JPN6009026151; Ｊ．　Ｉｍｍｕｎｏｌ．　（２０００）　ｖｏｌ．１６４，　ｎｏ．９，　ｐ．４４９３-４４９９
Attorney, Agent or Firm:
刑部 俊
川本 和弥
新見 浩一
清水 初志



 
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