Title:
ビタミンK依存性タンパク質発現を改善するための、ビタミンKエポキシドレダクダーゼサブユニット1の組換え同時発現
Document Type and Number:
Japanese Patent JP5339391
Kind Code:
B2
Abstract:
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.
Inventors:
Friedrich shy flinger
Ernst Behm
Ernst Behm
Application Number:
JP2012279460A
Publication Date:
November 13, 2013
Filing Date:
December 21, 2012
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
BAXTER HEALTHCARE S.A.
BAXTER HEALTHCARE S.A.
International Classes:
C12N5/10; C07K14/745; C12N15/09; C12P21/02
Foreign References:
| WO2006067116A1 | ||||
| WO2005030039A1 |
Other References:
J. Biol. Chem.,2005年 1月 7日,Vol.280, No.11,P.10540-10547
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka