Title:
RECOMBINANT COCCIDIOSIS VACCINE-5-7 EIMERIA SURFACE ANTIGEN
Document Type and Number:
Japanese Patent JP3023997
Kind Code:
B2
Abstract:
PURPOSE: To obtain a DNA encoding a precursor of an Eimeria merozoite surface antigen having an apparent molecular weight of about 23 kDa, determined by the SDS-PAGE.
CONSTITUTION: A protein having one or more immunoreactive determinant and/or antigen determinant of a surface antigen, a recombinant vector and a recombinant virus containing DNA encoding the protein and a transgenic microorganism containing the vector or the virus, are provided. Preparation methods of the protein and the transgenic microorganism are provided. A purified 23 kDa merozoite surface antigen itself, its 30 kDa precursor itself and a method for protecting poultry from coccidiosis using an Eimeria surface antigen, a precursor protein and/or fragment thereof, are presented. The protein or the fragment can be administered for the purpose of such protection either as a purified protein or in the form of DNA encoding the protein in an appropriate virus vector (e.g. vaccinia virus).
Inventors:
Mary-Helen Binger
Application Number:
JP2257391A
Publication Date:
March 21, 2000
Filing Date:
January 24, 1991
Export Citation:
Assignee:
Ef Hoffman-La Roche Age
International Classes:
C12N15/09; A61K39/012; A61K39/12; A61P31/04; A61P33/02; C07K1/22; C07K14/00; C07K14/435; C07K14/455; C12N1/21; C12N7/00; C12N15/30; C12P21/02; A61K39/00; C12R1/19; (IPC1-7): C07K14/455; A61K31/00; A61K39/012; C12N1/21; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)