RECOMBINED FIBROBLAST GROWTH FACTOR

Title:

RECOMBINED FIBROBLAST GROWTH FACTOR

Document Type and Number:

Japanese Patent JP2953574

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a DNA useful for producing a practical amount of the subject factor used for curing diseases having vascularization as a main disease condition and common to ophthalmology, dermatology and rheumatology and diseases on certain kinds of neoplasms including encephaloma high in a vas- forming ability.
SOLUTION: This recombined DNA encodes a human basic FGF(fibroblast growth factor) protein analogue, which has the activity of a FGF antagonist and which deletes the 1-33 residues of the amino acid residue in an arbitrary length. The recombined DNA is obtained by using a bacteriophage λ BB2 (ATCC No.40196) retaining the sequence of the human basic FGF as a DNA sequence source and modifying the sequence of the human basic FGF by a site-specific mutation method or the like.

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Inventors:

JON SHII FUIDESU
JUDEISU EE ABURAHAMU
ANDORYUU PUROTSUTAA

Application Number:

JP22637698A

Publication Date:

September 27, 1999

Filing Date:

August 10, 1998

Export Citation:

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Assignee:

SAIOSU INC

International Classes:

A61K38/22; A61P25/00; A61P25/28; C07K14/00; C07K14/435; C07K14/47; C07K14/50; C07K14/52; C12N1/21; C12N5/10; C12N15/09; C12N15/85; C12P21/02; A61K38/00; C12R1/19; C12R1/91; (IPC1-7): C12N15/09; C07K14/50; C12N1/21; C12N5/10; C12P21/02

Domestic Patent References:

JP2193A

Attorney, Agent or Firm:

Shusaku Yamamoto

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