Title:
REGULATABLE CHIMERIC ANTIGEN RECEPTOR
Document Type and Number:
Japanese Patent JP2023065409
Kind Code:
A
Abstract:
To provide regulatable chimeric antigen receptors (RCARs), to provide RCAR-expressing cells, and to provide manufacturing methods thereof.SOLUTION: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. Here, an RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain.SELECTED DRAWING: None
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Inventors:
BROGDON, Jennifer
ENGELS, Boris
GLASS, David Jonathan
GRANDA, Brian
HASTEWELL, John
LOEW, Andreas
MANNICK, Joan
MILONE, Michael
MURPHY, Leon
SELLERS, William Raj
SONG, Huijuan
VASH, Brian Edward
WEILER, Jan
WU, Qilong
ZHOU, Li
ENGELS, Boris
GLASS, David Jonathan
GRANDA, Brian
HASTEWELL, John
LOEW, Andreas
MANNICK, Joan
MILONE, Michael
MURPHY, Leon
SELLERS, William Raj
SONG, Huijuan
VASH, Brian Edward
WEILER, Jan
WU, Qilong
ZHOU, Li
Application Number:
JP2023017324A
Publication Date:
May 12, 2023
Filing Date:
February 08, 2023
Export Citation:
Assignee:
Novartis Age
The Trustees of the University of Pennsylvania
The Trustees of the University of Pennsylvania
International Classes:
C12N15/62; A61K35/12; A61K35/17; A61K35/76; A61K48/00; A61P35/00; C07K14/725; C07K16/28; C07K19/00; C12N5/10; C12N15/12; C12N15/13; C12N15/85
Attorney, Agent or Firm:
Michiko Matsutani
Yoko Sakurai
Yoko Sakurai