Title:
２型自然リンパ球細胞、インターロイキン３３、及び／またはインターフェロン誘導性タンパク質４４による癌免疫の調節
Document Type and Number:
Japanese Patent JP7373543
Kind Code:
B2
Abstract:
The present invention provides methods of modulating of cancer immunity using type 2 innate lymphoid cells (ILC2s), interleukin 33 (IL-33), IFI44 or combination thereof. Also provided are methods of preventing tumor metastasis and/or cancer progression by treatment with therapies comprising type 2 innate lymphoid cells (ILC2s), interleukin 33 (IL-33), IFI44 or combination thereof. Also provided are diagnostic methods for assessing cancer prognosis.
Inventors:
Jeffreys Wilfred
Saranco Baileina Yurinina
Saranco Baileina Yurinina
Application Number:
JP2021199202A
Publication Date:
November 02, 2023
Filing Date:
December 08, 2021
Export Citation:
Assignee:
Cava Healthcare Incorporated
International Classes:
A61K38/17; A61K35/15; A61K35/17; A61K35/28; A61K38/19; A61K38/20; A61K38/21; A61K39/02; A61K39/12; A61K39/39; A61K39/395; A61K48/00; A61P1/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| JP2007523089A |
Foreign References:
| US20120004289 |
Other References:
Gao Kら,Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and m,Cancer Lett. 2013 Jul 28;335(2):463-71.,2013年
Gao Xら,Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD,J Immunol. 2015 Jan 1;194(1):438-45. Epub 2014 Nov 26.,2014年
Villarreal DOら,Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity.,Cancer Res. 2014 Mar 15;74(6):1789-800. Epub 2014 Jan 21.,2014年
Martinez-Gonzalez Iら,Lung ILC2s link innate and adaptive responses in allergic inflammation.,Trends Immunol. 2015 Mar;36(3):189-95. Epub 2015 Feb 19.,2015年02月19日
JUYANG KIM,An IL-33 immunotherapy that blocks tumor growth by establishing innate lymphoid cells. (LB52),The FASEB Journal Vol. 28, No. 1_supplement April 2014Published Online:1 Apr 2014Abstract Number:LB,2014年
Gao Xら,Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD,J Immunol. 2015 Jan 1;194(1):438-45. Epub 2014 Nov 26.,2014年
Villarreal DOら,Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity.,Cancer Res. 2014 Mar 15;74(6):1789-800. Epub 2014 Jan 21.,2014年
Martinez-Gonzalez Iら,Lung ILC2s link innate and adaptive responses in allergic inflammation.,Trends Immunol. 2015 Mar;36(3):189-95. Epub 2015 Feb 19.,2015年02月19日
JUYANG KIM,An IL-33 immunotherapy that blocks tumor growth by establishing innate lymphoid cells. (LB52),The FASEB Journal Vol. 28, No. 1_supplement April 2014Published Online:1 Apr 2014Abstract Number:LB,2014年
Attorney, Agent or Firm:
Nagoya International Patent Attorney Corporation