Title:
eIF4E発現の調整
Document Type and Number:
Japanese Patent JP4672664
Kind Code:
B2
Abstract:
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
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Inventors:
Susan M Flyer
Kenneth W. Dobby
Eric G. Marcusson
Eric E Swage
Barklishen Butt
Jeremy Earl Graph
Bruce W. Conicec
Kenneth W. Dobby
Eric G. Marcusson
Eric E Swage
Barklishen Butt
Jeremy Earl Graph
Bruce W. Conicec
Application Number:
JP2006527039A
Publication Date:
April 20, 2011
Filing Date:
September 17, 2004
Export Citation:
Assignee:
Isis Pharmaceuticals, Inc.
International Classes:
C12N15/113; A61K31/7088; A61P35/00; A61K38/00
Domestic Patent References:
| JP2002509732A |
Foreign References:
| US20030087852 | ||||
| US20020165189 | ||||
| US5898031 |
Other References:
Mol. Cell. Biol., 1991, Vol.11, No.11, p.5435-5445
Int. J. Biochem. Cell Biol., 1999, Vol.31, p.59-72
Hepatology, Jul.2003, Vol.38, p.158-166
J. Biol. Chem., 1992, Vol.267, No.16, p.11495-11499
Int. J. Biochem. Cell Biol., 1999, Vol.31, p.59-72
Hepatology, Jul.2003, Vol.38, p.158-166
J. Biol. Chem., 1992, Vol.267, No.16, p.11495-11499
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa
Kure Hidenori
Samejima Mutsumi
Masahiro Nitta
Nagatoshi Shinagawa
Kure Hidenori