Title:
テロメラーゼ陽性細胞におけるテロメア長の調節および癌治療
Document Type and Number:
Japanese Patent JP2008536822
Kind Code:
A
Abstract:
Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.
Inventors:
Bondarev, Igor, Yi.
Application Number:
JP2008503271A
Publication Date:
September 11, 2008
Filing Date:
March 27, 2006
Export Citation:
Assignee:
Alt Solutions Incorporated
International Classes:
A61K31/522; A61K31/513; A61K31/7072; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D473/18
Domestic Patent References:
| JPH11123100A | 1999-05-11 | |||
| JP2007524668A | 2007-08-30 | |||
| JP2000507211A | 2000-06-13 |
Foreign References:
| US5166140A | 1992-11-24 |
Other References:
JPN7012000981; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓｅａｒｃｈ Ｓｕｐｐｌｅｍｅｎｔ Ｎｏ．１, 2001, ２１１-２１２
JPN6013007762; 医学のあゆみ １９４， ３, 2000, ｐ．１４８-１５１
JPN6013007765; 日本臨床 ６２， ７, 2004, ｐ．１２７７-１２８２
JPN6013007768; 日本臨床 ６２， ７, 2004, ｐ．１２７１-１２７６
JPN6013007770; 大原智子他: 日本癌学会総会記事 ６２ｎｄ, 2003, ｐ．５２６
JPN6013007772; 住昌彦他: 臨床血液 ４４， ８, 2003, ｐ．６７９
JPN6013007762; 医学のあゆみ １９４， ３, 2000, ｐ．１４８-１５１
JPN6013007765; 日本臨床 ６２， ７, 2004, ｐ．１２７７-１２８２
JPN6013007768; 日本臨床 ６２， ７, 2004, ｐ．１２７１-１２７６
JPN6013007770; 大原智子他: 日本癌学会総会記事 ６２ｎｄ, 2003, ｐ．５２６
JPN6013007772; 住昌彦他: 臨床血液 ４４， ８, 2003, ｐ．６７９
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Yuko Matsuniya
Ishii Teiji
Satoshi Fujita
Yuko Matsuniya