ペルオキシソーム増殖因子活性化受容体の調節物質

Japanese Patent JP2005509590

A

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH₂- or -CH₂CH₂-; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R₁ and W. R₁ is -(CH₂)_n-CH(OR₂)-(CH₂)_mE, -(CH)-C(OR₂)-(CH₂)_mE, -(CH₂)_n-CH(Y)-(CH₂)_mE or -(CH)-C(Y)-(CH₂)_mE; wherein E is COOR₃, C₁-C₃-alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C₁-C₆ alkyl, haloalkyl and aryl-C_0-4-alkyl; R₂ is -H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, -COR₄, -COOR₄, -CONR₅R₆, -C(S)R₄, -C(S)OR₄ or -C(S)NR₅R₆. R₃ is -H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is -O-, -CH₂-, -CH₂CH₂- or -CH-CH- and is bonded to a carbon atom in Phenyl Ring A that is ortho to R₁. R₄-R₆ are independently -H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

JPH07119201	[Title of the Invention] A naphthylsulfonylalkylcarboxylic acid derivative.
JP2004537595	Fatty acid derivatives, their production methods and uses
WO/1998/022081	USE OF OCTOXYGLYCERIN IN A COSMETIC AND/OR DERMATOLOGICAL COMPOSITION AS ACTIVE AGENT FOR THE TREATMENT OF SEBORRHOEA AND/OR ACNE

Dawn Alisa Brooks
Alan M Warshaw Ski
Charzad Montrose-La Feza Day
Anne Leifel-Mirror
Rawes priet
Isabel Rojo
Jose Alfredo Martin
Maria Rosario González Garcia
Alicia Trad
Rafael Ferito Crespo
Carlos Lamas-Peteira
Maria Martin-Ortega Fingel
Robert jay ardecky

JP2003503584A

April 14, 2005

May 30, 2002

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ELI LILLY AND COMPANY

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Kyousei Tamura
Hiromitsu Takayama
Minato Saito

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