Title:
プロスタサイクリン(PGI2)受容体に関連する障害の処置に有用なPGI2受容体の調節因子
Document Type and Number:
Japanese Patent JP5536752
Kind Code:
B2
Abstract:
The present invention relates to amide derivatives of Formula (Xllla) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor.Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Inventors:
Trang, Chu-An
Chen, Wei Chao
Kramer, Brian A.
Saddek, Abu Jay. M.
Sifrina, Hannah El.
Shin, Yong-Chun
Baller, Preza
Zou, Nin
Chen, Wei Chao
Kramer, Brian A.
Saddek, Abu Jay. M.
Sifrina, Hannah El.
Shin, Yong-Chun
Baller, Preza
Zou, Nin
Application Number:
JP2011500799A
Publication Date:
July 02, 2014
Filing Date:
March 17, 2009
Export Citation:
Assignee:
Arena Pharmaceuticals, Incorporated
International Classes:
C07C271/28; A61K31/192; A61K31/27; A61K31/381; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4965; A61P1/04; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/16; A61P13/12; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P43/00; C07C271/12; C07C275/24; C07C275/28; C07C275/30; C07C275/34; C07C309/15; C07D213/75; C07D241/20; C07D277/20; C07D277/48; C07D333/36
Domestic Patent References:
| JP56086417A |
Foreign References:
| WO2002060388A1 | ||||
| US20070213302 |
Other References:
SEILER S M,2-[3-[2-(4,5-DIPHENYL-2-OXAZOLYL) ETHYL] PHENOXY] ACETIC ACID (BMY 42393): A NEW,STRUCTURALLY-NOVEL PROSTACYCLIN PARTIAL AGONIST:1)INHIBITION,THROMBOSIS RESEARCH,米国,1994年 4月15日,V74 N2,P115-123
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita