Title:
代謝競合による汚染非ヒトシアル酸の除去
Document Type and Number:
Japanese Patent JP2012501661
Kind Code:
A
Abstract:
The disclosure provides a method of reducing or eliminating Neu5Gc in a cell culture or in a human subject. The method includes flooding the system with the human sialic acid i\7-acetylneuraminic acid (Neu5Ac) in glycosidically-bound or free form, or its precursor N-acetylmannosamine (ManNAc) in an amount sufficient to metabolically compete out the Neu5Gc, either as it enters the cells for the first time or when it recycles from break-down of preexisting cellular molecules. Additionally, Neu5Ac feeding results in reduction of Neu5Gc expression even in some animal cells capable of Neu5Gc production.
Inventors:
Valki, Agit
Dias, Sandra
Rachel taylor
Dias, Sandra
Rachel taylor
Application Number:
JP2011526302A
Publication Date:
January 26, 2012
Filing Date:
September 09, 2009
Export Citation:
Assignee:
The Legends of the Universty of California
International Classes:
C12N5/071; A23L1/30; A61K31/7008; A61K31/7012; A61K31/7088; A61P29/00; A61P35/00; C12N5/073; C12N5/074
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
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