Title:
アムホテリシンＢの毒性が低減された誘導体の規模変更可能な合成法
Document Type and Number:
Japanese Patent JP6755859
Kind Code:
B2
Abstract:
Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
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Inventors:
Burke, martin dee
Uno, Bryce E
Raksit, Sovic
Uno, Bryce E
Raksit, Sovic
Application Number:
JP2017518431A
Publication Date:
September 16, 2020
Filing Date:
October 16, 2015
Export Citation:
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
International Classes:
C07H17/08
Domestic Patent References:
| JP4108797A |
Foreign References:
| WO2014059436A1 | ||||
| WO2014165676A1 | ||||
| WO2015175875A1 |
Other References:
Nature Chemistry,2012年,Vol.4,pp.996-1003
Journal of the American Chemical Society,2012年,Vol.134,pp.9755-9761
Journal of the American Chemical Society,2007年,Vol.129,pp.13804-13805
Journal of the American Chemical Society,2012年,Vol.134,pp.9755-9761
Journal of the American Chemical Society,2007年,Vol.129,pp.13804-13805
Attorney, Agent or Firm:
Hiroshi Higuchi