Title:
レソルビン:治療処置用のバイオテンプレート
Document Type and Number:
Japanese Patent JP5410314
Kind Code:
B2
Abstract:
The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
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Inventors:
Charles N. Sirhan
Application Number:
JP2010012499A
Publication Date:
February 05, 2014
Filing Date:
January 22, 2010
Export Citation:
Assignee:
The Brigham And Women's Hospital Incorporated
International Classes:
A61K31/557; C07C59/42; A61K31/19; A61K31/232; A61P25/00; A61P29/00; C07C59/48; C07C69/732; C07F7/18
Domestic Patent References:
| JP2005529945A |
Foreign References:
| WO2001060778A1 |
Other References:
SERHAN,C.N. et al,Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing,Journal of Experimental Medicine,2000年,Vol.192, No.8,p.1197-1204
Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate,Journal of Lipid Research,1984年,Vol.25, No.5,p.507-17
KIM,H.Y. et al,Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS,Prostaglandins,1989年,Vol.37, No.1,p.105-19
YAMAUCHI,R. et al,Autoxidation and photosensitized oxidation of methyl eicosapentaenoate: secondary oxidation products,Agricultural and Biological Chemistry,1985年,Vol.49, No.7,p.2077-82
C.N.Serhan et al,J.Exp.Med.,2002年10月21日,Vol.196, No.8,pp.1025-1037
Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate,Journal of Lipid Research,1984年,Vol.25, No.5,p.507-17
KIM,H.Y. et al,Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS,Prostaglandins,1989年,Vol.37, No.1,p.105-19
YAMAUCHI,R. et al,Autoxidation and photosensitized oxidation of methyl eicosapentaenoate: secondary oxidation products,Agricultural and Biological Chemistry,1985年,Vol.49, No.7,p.2077-82
C.N.Serhan et al,J.Exp.Med.,2002年10月21日,Vol.196, No.8,pp.1025-1037
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita