Title:
呼吸域ザフィルルカスト粒子の調製方法
Document Type and Number:
Japanese Patent JP6883039
Kind Code:
B2
Abstract:
A method for the preparation of respirable zafirlukast monohydrate particles comprises the steps of preparation of an aqueous suspension of amorphous zafirlukast; size-reduction with conversion of the suspended zafirlukast into crystalline monohydrate nanoparticles; and isolation of the crystalline zafirlukast in the form of a dry powder. Also provided are zafirlukast respirable particles characterized by comprising crystalline monohydrate zafirlukast. Pharmaceutical compositions comprising the particles are also disclosed, as is the use of the particles or compositions for the treatment of respiratory diseases.
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Inventors:
Costa, Unis
Compos, Susana
Neves, Philip
Compos, Susana
Neves, Philip
Application Number:
JP2018531556A
Publication Date:
June 02, 2021
Filing Date:
December 15, 2016
Export Citation:
Assignee:
Hobione Scientia Limited
International Classes:
A61K31/404; A61K9/14; A61K9/19; A61K9/72; A61K47/18; A61K47/26; A61K47/30; A61P11/00; A61P11/06; A61P11/08
Domestic Patent References:
| JP2011528343A | ||||
| JP4266824A | ||||
| JP2008533174A | ||||
| JP2005508220A | ||||
| JP4266872A | ||||
| JP2015500268A | ||||
| JP2013525338A |
Foreign References:
| WO2008126797A1 | ||||
| US20040058901 | ||||
| WO2015154084A1 |
Other References:
Acta Cryst.,2004年,C60,pp.o843-o846
Attorney, Agent or Firm:
西浦 ▲嗣▼晴
High Miki Yoshiki
Tadashi Deyama
High Miki Yoshiki
Tadashi Deyama