ミセル調製による活性物質のレチノール誘導体強化

Title:

ミセル調製による活性物質のレチノール誘導体強化

Document Type and Number:

Japanese Patent JP4147114

Kind Code:

B2

Abstract:

This invention relates to the synthesis of sodium salts of retinoyls derivatives, capable of potentiating the efficacy of therapeutically active compounds, for example cytotoxic compounds used in the treatment of cancer. These compounds have been shown to increase the pharmacological activity of a conventional paclitaxel formulation and to make it possible to manufacture a new formulation of paclitaxel, exhibiting improved solubility, improved storage properties, and increased therapeutic efficacy as shown in the enclosed examples.

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Inventors:

Oleg Strelchenoch
Julian Aleksov

Application Number:

JP2002589484A

Publication Date:

September 10, 2008

Filing Date:

March 05, 2002

Export Citation:

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Assignee:

ARDENIA INVESTMENTS LTD.

International Classes:

C07C309/18; C07D305/14; A01N37/12; A01N37/44; A61K9/10; A61K9/107; A61K31/195; A61K31/198; A61K31/203; A61K31/337; A61K31/40; A61K45/00; A61P31/00; A61P35/00; C07C309/17; C07C309/22; C07C313/00; C07C313/02; C07C313/04; C07D493/00; C07D

Domestic Patent References:

JP3500767A
JP63101347A
JP47048266A

Attorney, Agent or Firm:

Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima

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