可逆的不死化させた嗅神経鞘グリア、およびニューロン再生を促進するためのその使用

Japanese Patent JP2007536901

A

The present invention is based on the capacity of the Olfactory Ensheathing Glia (OEG) to foster axonal regeneration in the adult mammalian central nervous system (CNS). This specific capacity is probably due to a combination of several factors, such as the molecular composition of cellular membrane and/or the capacity to secrete some molecules; combined with the capacity to reduce glial scar and accompany new growing axon in the damaged CNS. We have developed immortalised cell lines from primary human OEGs. The cells were cultured from post-mortem human tissue from donors and immortalised using a reversible system. Some of these OEG human clonal cell lines were selected by their ability to promote axonal regeneration from adult rat retinal ganglion neurons in a similar fashion to primary OEGs. These cell lines, alone or in pharmaceutical compositions comprising these cells, may be used to repair neuronal damage in the CNS.

Maria Theresa Moreno Flores
Maria Hessus Martin Bermech
Jessous Avila de Grado
Francisco Wandsel Fraud
Philip Lim
Erica Pastrana Isquierdo
National Research Counsel Canada

JP2006520020A

December 20, 2007

July 19, 2004

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

C12N5/10; A61K35/30; A61L27/00; A61P25/00; A61P43/00; C12N5/079; C12N5/0793; C12N15/09; A61K31/522; A61K38/12; A61P35/00

JP2003174870A

2003-06-24

WO2002074157A2	2002-09-26
WO2002074968A1	2002-09-26
WO2001030982A1	2001-05-03
WO2001066120A1	2001-09-13

Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro

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