Title:
RIBOFLAVIN DERIVATIVE
Document Type and Number:
Japanese Patent JPH01132586
Kind Code:
A
Abstract:
NEW MATERIAL:Vitamin B2 acid lactone. USE:A red tide-controlling agent which has action to inhibit the microorganism causing red tide (Chattonella antiqua) from growing. PREPARATION:For example, 7,8-dimethyl-10-(2,3,4-trihydroxy-4-carboxybutyl)-iso- alloxazine (vitamin B2 acid) of formula II, a flavin derivative produced by a kind of mushroom, SUEHIROTAKE (Schizorhyllum commune), is dissolved in n-butanol, then N,N-dicyclohexylcarbodiimide is added to the solution to effect the condensation reaction under light-shielded conditions with stirring at room temperature for 18 hours. Then, the reaction mixture is subjected to medium-pressure preparative chromatography to collect vitamin B2 acid lactone.
Inventors:
TACHIBANA KIYOSHI
TAKAHASHI MITSUNAO
MATOBA YASUHIRO
YAMAUCHI SHIN
SADA NORIMASA
TODA TOKU
TAKAHASHI MITSUNAO
MATOBA YASUHIRO
YAMAUCHI SHIN
SADA NORIMASA
TODA TOKU
Application Number:
JP29082287A
Publication Date:
May 25, 1989
Filing Date:
November 17, 1987
Export Citation:
Assignee:
HAKUSUI CHEM IND
International Classes:
A61K31/525; A61K31/519; A61P3/02; C07D475/14; (IPC1-7): A61K31/525; C07D475/14
Attorney, Agent or Firm:
Aoyama
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