Title:
リボヌクレオシド-誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP4473445
Kind Code:
B2
Abstract:
The ribonucleoside-derivatives serve for the synthesis of ribonucleic acids and comprise a triple substituted silyloxymethyl-group as a protection-group on the oxygen atom in 2'-position. The ribonucleoside-derivatives may be suitably protected on the nucleo-base and on the oxygen in 5'-position also. The new protection-groups in 2'-O-position are superior to conventional such protection-groups as they are not subject to isomerization and give higher coupling yields. The general formula of the ribonucleoside-derivative is: whereby R1 is a base of the purine- or pyrimidine-family or a derivative of such a base, R2 is a proton or a substituted derivative of phosphonic acid, R3 is a proton or a suitable protection-group, R4, R5, R6 are advantageously three identical or different alkyl- or aryl-substituents which together comprise between 6 and 30 carbon atoms.
Inventors:
Pitch, stefan
Weiss, Patrick, Ah.
Jenny, Luci
Weiss, Patrick, Ah.
Jenny, Luci
Application Number:
JP2000509723A
Publication Date:
June 02, 2010
Filing Date:
August 17, 1998
Export Citation:
Assignee:
Qiagen AG
International Classes:
C07H19/06; C07F7/18; C07H19/16; C07H21/00; C07H21/02; C07H23/00
Other References:
ANTONSEN, OEYVIND, et al.,PREPARATION OF MONOSILYL ETHERS OF VICINAL DIOLS,ACTA CHEM. SCAND.,1992年,46(8),pp.757-760
GUNDERSEN, LISE LOTTE, et al.,ARYL- AND ALKYNYLTRIISOPROPOXYTITANIUM REAGENTS IN REGIOSELECTIVE CARBON-CARBON BOND FORMATION IN AZINES,TETRAHEDRON,1992年,48(27),pp.5647-5656
ANTONSEN, OEYVIND, et al.,CROSS ALDOL PRODUCTS FROM.ALPHA.-HALOALKOXYSILANES AND SILYL ENOL ETHERS,ACTA CHEM. SCAND.,1992年,46(2),pp.172-177
GUNDERSEN, LISE LOTTE, et al.,CHLOROMETHOXYSILANES AS PROTECTINF REAGENTS FOR STERICALLY HINERED ALCOHOLS,ACTA CHEM. SCAND.,1989年,43(7),pp.706-709
BENNECHE, TORE, et al.,(TERT-BUTYLDIMETHYLSILYLOXY)METHYL CHLORIDE: SYNTHESIS AND USE AS N-PROTECTING GROUP IN PYRIMIDINONES,ACTA CHEM. SCAND., SER. B.,1988年,B42(6),pp.384-389
USMAN, N., et al.,AUTOMATED CHEMICAL SYNTHESIS LONG OLIGORIBONUCLEOTIDES USING 2'-O-SILYLATED RIBONUCLEOSIDE 3'-O-PHOSPHORAMIDITES CONTROLLED-PORE GLASS SUPPORT SYNTHESIS 43-NUCLEOTIDE SEQUENCE SIMILAR 3'-HALF MOLECULE OF AN ESCHERICHIA COLI FORMYLMETHIONINE tRNA,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1987年,109(25),pp.7845-7854
GUNDERSEN, LISE LOTTE, et al.,ARYL- AND ALKYNYLTRIISOPROPOXYTITANIUM REAGENTS IN REGIOSELECTIVE CARBON-CARBON BOND FORMATION IN AZINES,TETRAHEDRON,1992年,48(27),pp.5647-5656
ANTONSEN, OEYVIND, et al.,CROSS ALDOL PRODUCTS FROM.ALPHA.-HALOALKOXYSILANES AND SILYL ENOL ETHERS,ACTA CHEM. SCAND.,1992年,46(2),pp.172-177
GUNDERSEN, LISE LOTTE, et al.,CHLOROMETHOXYSILANES AS PROTECTINF REAGENTS FOR STERICALLY HINERED ALCOHOLS,ACTA CHEM. SCAND.,1989年,43(7),pp.706-709
BENNECHE, TORE, et al.,(TERT-BUTYLDIMETHYLSILYLOXY)METHYL CHLORIDE: SYNTHESIS AND USE AS N-PROTECTING GROUP IN PYRIMIDINONES,ACTA CHEM. SCAND., SER. B.,1988年,B42(6),pp.384-389
USMAN, N., et al.,AUTOMATED CHEMICAL SYNTHESIS LONG OLIGORIBONUCLEOTIDES USING 2'-O-SILYLATED RIBONUCLEOSIDE 3'-O-PHOSPHORAMIDITES CONTROLLED-PORE GLASS SUPPORT SYNTHESIS 43-NUCLEOTIDE SEQUENCE SIMILAR 3'-HALF MOLECULE OF AN ESCHERICHIA COLI FORMYLMETHIONINE tRNA,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1987年,109(25),pp.7845-7854
Attorney, Agent or Firm:
Yuichi Yamada
Yasuhito Suzuki
Yasuhito Suzuki