Title:
リボスイッチ、リボスイッチによる、構造を基礎とする化合物設計、ならびにリボスイッチの使用方法およびリボスイッチを伴う組成物
Document Type and Number:
Japanese Patent JP2008518630
Kind Code:
A
Abstract:
Riboswitches and modified versions of riboswitches can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments. Compounds can be used to stimulate, active, inhibit and/or inactivate riboswitches. Atomic structures of riboswitches can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches.
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Inventors:
Breaker, Ronald Earle.
Rim, Jinsu
Robert Bati
Blount, Kenneth F.
Pushkarts, Isabella
Rim, Jinsu
Robert Bati
Blount, Kenneth F.
Pushkarts, Isabella
Application Number:
JP2007540181A
Publication Date:
June 05, 2008
Filing Date:
November 08, 2005
Export Citation:
Assignee:
YALE UNIVERSITY
International Classes:
A61K31/522; C12N15/09; A61K45/00; A61P31/04; C12N15/115; C12Q1/25; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| JP2003520940A | 2003-07-08 |
Foreign References:
| WO2004027035A2 | 2004-04-01 |
Other References:
JPN6011033316; Ｎａｔｕｒｅ ４３２, 20041118, ４１１-５
JPN6011033319; Ｃｈｅｍ． Ｂｉｏｌ． １１, 200412, １７２９-４１
JPN7011002311; Ｃｅｌｌ １１３, 2003, ５７７-８６
JPN6011033319; Ｃｈｅｍ． Ｂｉｏｌ． １１, 200412, １７２９-４１
JPN7011002311; Ｃｅｌｌ １１３, 2003, ５７７-８６
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura