Title:
疼痛制御及び脱髄損傷の回復におけるN-2-ヒドロキシ-エチル-ピペラジン-N’-2-エタンスルホン酸(HEPES)の役割
Document Type and Number:
Japanese Patent JP2013505264
Kind Code:
A
Abstract:
Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.
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Inventors:
Danhoff Ivan E.
Application Number:
JP2012529955A
Publication Date:
February 14, 2013
Filing Date:
September 17, 2010
Export Citation:
Assignee:
NORTH TEXAS MEDICAL ASSOCIATES
International Classes:
A61K31/495; A61K9/08; A61K31/135; A61K31/138; A61K31/15; A61K31/34; A61K31/4406; A61K31/4525; A61K31/5513; A61K45/00; A61K47/04; A61P21/00; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00
Domestic Patent References:
| JPH11504050A | 1999-04-06 |
Foreign References:
| WO2009004082A2 | 2009-01-08 |
Other References:
JPN6014034482; Ｂｒａｉｎ Ｒｅｓｅａｒｃｈ Ｖｏｌ．８６８, 2000, ｐ．２０２-２１４
JPN6014034483; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．４９， Ｎｏ．３, 1995, ｐ．３９９-４１０
JPN6014034485; Ｊｏｕｒｎａｌ ｏｆ Ａｆｆｅｃｔｉｖｅ Ｄｉｓｏｒｄｅｒｓ Ｖｏｌ．８６, 2005, ｐ．１-１０
JPN6014034483; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．４９， Ｎｏ．３, 1995, ｐ．３９９-４１０
JPN6014034485; Ｊｏｕｒｎａｌ ｏｆ Ａｆｆｅｃｔｉｖｅ Ｄｉｓｏｒｄｅｒｓ Ｖｏｌ．８６, 2005, ｐ．１-１０
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi