Title:
ルテニウムヒドリド錯体、アルコール化合物の製造方法およびラセミ体カルボニル化合物の分割方法
Document Type and Number:
Japanese Patent JP4919562
Kind Code:
B2
Abstract:
trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure reduction and argon introduction while stirring the solution for deaeration. A hydrogen tank was then connected to the autoclave, and after replacing the air inside an introduction tube with hydrogen, the pressure inside the autoclave was adjusted to 5 atmospheres and then hydrogen was released until the pressure dropped to 1 atmosphere. After repeating this procedure 10 times, the hydrogen pressure was adjusted to 8 atmospheres and stirring at 25° C. was performed for 12 hours. By concentrating the solution obtained by depressurization and subjecting the crude product to simple distillation, (R)-1-phenylethanol (yield: 95%) in the form of a colorless oily substance was obtained at an ee of 99%.
Inventors:
Takeshi Okuma
Koizumi Masatoshi
Cillian Munitz
Ryoji Noyori
Koizumi Masatoshi
Cillian Munitz
Ryoji Noyori
Application Number:
JP2001301852A
Publication Date:
April 18, 2012
Filing Date:
September 28, 2001
Export Citation:
Assignee:
Nippon Soda Co., Ltd.
International Classes:
C07F9/50; B01J31/12; B01J31/18; B01J31/24; C07B41/02; C07B53/00; C07B61/00; C07C29/145; C07C33/03; C07C33/22; C07C35/08; C07C41/26; C07C41/44; C07C43/196; C07C45/85; C07C49/403; C07C67/31; C07C67/56; C07C69/732; C07C69/84; C07C211/27; C07C213/00; C07C215/30; C07D301/00; C07D301/32; C07D303/22; C07D303/26; C07D317/24; C07F15/00
Domestic Patent References:
| JP11189600A | ||||
| JP11139791A |
Foreign References:
| WO2001058843A1 |
Attorney, Agent or Firm:
Masaki Hirota