Title:
SPEX組成物および使用方法
Document Type and Number:
Japanese Patent JP2006524489
Kind Code:
A
Abstract:
The present invention provides novel polypeptides and other factors identified as being expressed in spleen tissue and related to lymphocyte activity and the immune response. These compounds are referred to herein as SPEX compounds. Human and murine homologues of SPEX polypeptides and polynucleotides are provided including two murine alleles. The invention further provides polynucleotides encoding the polypeptides and complementary nucleic acid sequences thereof. Also provided are immunogens, expression vectors, and antibodies related to the SPEX polypeptides and polynucleotides. The present invention discloses the use of anti-SPEX antibodies in the regulation of lymphocyte activity and the regulation of the immune response.
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Inventors:
Jonathan Kay
Beverly Wilkinson
Beverly Wilkinson
Application Number:
JP2006500102A
Publication Date:
November 02, 2006
Filing Date:
April 29, 2004
Export Citation:
Assignee:
NOVARTIS AG
THE SCRIPPS RESEARCH INSTITUTE
THE SCRIPPS RESEARCH INSTITUTE
International Classes:
C12N15/09; A61K31/4745; A61K31/573; A61K38/13; A61K39/395; C07H21/04; C07K14/47; C07K16/18; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/10; C12N15/12; G01N33/15; G01N33/50; C12N
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima