Title:
スルファメート結合を有するＳＴＩＮＧモジュレーター化合物、及び製造及び使用の方法
Document Type and Number:
Japanese Patent JP7337086
Kind Code:
B2
Abstract:
The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
Inventors:
Shabari, Jeffrey
England, Dylan Bradley
Gigstad, Kenneth M.
Gold, Alexandra Yee.
Greenspan, Paul
Fu, Yongbo
Fan, Shi-chun
Langston, Stephen Paul
Hirotake Mizutani
Si, Jean
Viskosil, Stephan
Shu, He
England, Dylan Bradley
Gigstad, Kenneth M.
Gold, Alexandra Yee.
Greenspan, Paul
Fu, Yongbo
Fan, Shi-chun
Langston, Stephen Paul
Hirotake Mizutani
Si, Jean
Viskosil, Stephan
Shu, He
Application Number:
JP2020550712A
Publication Date:
September 01, 2023
Filing Date:
March 22, 2019
Export Citation:
Assignee:
Takeda GmbH
International Classes:
C07H19/213; A61K31/708; A61K31/7084; A61K39/00; A61K45/00; A61K48/00; A61P35/00; A61P37/02; A61P37/04; A61P43/00; C07F9/6561
Domestic Patent References:
| JP2017518302A |
Foreign References:
| WO2019118839A1 | ||||
| WO2017161349A1 | ||||
| WO2016096174A1 | ||||
| WO2015074145A1 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto