【発明の名称】N-スルホニルインドリン誘導体の製造方法および医薬組成物

Japanese Patent JP3195381

B2

Compounds of formula: in which - R1 denotes a halogen atom, a C1-C4 alkyl or alkoxy, a hydroxyl or a benzyloxy, cyano, trifluoromethyl, nitro or amino group; - R2 denotes a C1-C6 alkyl, a C3-C7 cycloalkyl, a C5-C7 cycloalkene, a phenyl, unsubstituted or mono- or polysubstituted by a C1-C4 alkyl or alkoxy, a halogen or a trifluoromethyl, nitro or amino group; - R3 denotes a hydrogen atom or a C1-C4 alkyl; - R4 denotes a carboxyl group, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group or a carboxamide group of formula CONR6R7; - R5 denotes a C1-C4 alkyl, 1-naphthyl, 2-naphthyl, 5-dimethylamino-1-naphthyl, phenyl, unsubstituted or substituted by one or more substituents chosen from a halogen, a C1-C4 alkyl, a trifluoromethyl, nitro, amino group free or substituted by one or 2 C1-C4 alkyls, a hydroxyl, a C1-C4 alkoxy, a C1-C4 alkenoxy, a C1-C4 alkylthio or a trifluoromethoxy, benzyloxy, cyano, carboxyl, C1-C4 alkoxycarbonyl, carbamoyl or C1-C4 alkylamido group or, when m = 0, R5 may denote a group: - each of R6 and R7 independently denotes hydrogen, a C1-C6 alkyl, a phenylalkyl in which the alkyl is C1-C4 or R6 and R7 together form a -(CH2)p- group; - n denotes 0, 1 or 2; - m denotes 0, 1 or 2; - p denotes 4, 5 or 6; and their optional salts. These compounds have an affinity for the vasopressin and ocytocin receptors.

Jean Bagon
Paul de Cowante
Dino Nizato
Claude Pluzant
Claudine Sradii-Legal

JP19207891A

August 06, 2001

July 31, 1991

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SANOFI-SYNTHELABO

A61K31/403; A61K31/404; A61P1/00; A61P9/00; A61P13/12; A61P25/00; C07C311/08; C07C311/13; A61K31/40; C07C311/21; C07D209/42; C07D405/12; (IPC1-7): C07D209/42; A61K31/404; A61P1/00; A61P9/00; A61P13/12; A61P25/00; C07D405/12

【文献】米国特許3838167(US,A)

Aoyama Ryo (1 person outside)

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