Title:
トリテルペンであるサポニン、その合成法および使用
Document Type and Number:
Japanese Patent JP6770596
Kind Code:
B2
Abstract:
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
Inventors:
David Jin
Michael adams
Cayden
Nicholas Pearl
Annie Wong
Philip Livingston
Govind Rugpathy
Michael adams
Cayden
Nicholas Pearl
Annie Wong
Philip Livingston
Govind Rugpathy
Application Number:
JP2019000534A
Publication Date:
October 14, 2020
Filing Date:
January 07, 2019
Export Citation:
Assignee:
Sloan-Kettering Institute for Cancer Research
International Classes:
C07J63/00
Other References:
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Synlett,2003年,9,1323-1326
Journal of the American Chemical Society,DOI:10.1021/ja0422007
Journal of the American Chemical Society,DOI:10.1021/ja062364i
Phytochemistry,DOI:10.1016/S0031-9422(00)81518-6
Natural Medicines,1995年,49(4),478-83
Phytochemistry,DOI:10.1016/0031-9422(96)00085-4
Synlett,2003年,9,1323-1326
Journal of the American Chemical Society,DOI:10.1021/ja0422007
Journal of the American Chemical Society,DOI:10.1021/ja062364i
Phytochemistry,DOI:10.1016/S0031-9422(00)81518-6
Natural Medicines,1995年,49(4),478-83
Phytochemistry,DOI:10.1016/0031-9422(96)00085-4
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita