Title:
Fibronectin-based scaffold domain protein that binds to myostatin
Document Type and Number:
Japanese Patent JP6346895
Kind Code:
B2
Abstract:
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
Inventors:
Sharon Claude
Linda Engle
Dartha Lipovsek
Maravi Maddy Lady
Ginger Chao Lake Straw
Joanna Swain
Wen Jun Jiao
Hoi Wei
Aaron P. Yamunuk
Vidyashankar Lamamurti
Alexander T. Kozic
Martin Jay Corbett
Stanley Richard Cristech Jr.
Linda Engle
Dartha Lipovsek
Maravi Maddy Lady
Ginger Chao Lake Straw
Joanna Swain
Wen Jun Jiao
Hoi Wei
Aaron P. Yamunuk
Vidyashankar Lamamurti
Alexander T. Kozic
Martin Jay Corbett
Stanley Richard Cristech Jr.
Application Number:
JP2015532042A
Publication Date:
June 20, 2018
Filing Date:
September 12, 2013
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07K14/78; A61K38/39; A61K39/395; A61K47/42; A61K47/50; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P11/00; A61P13/12; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P21/02; A61P29/00; A61P31/18; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N33/53; G01N33/566
Domestic Patent References:
| JP2012512641A | ||||
| JP2003525487A |
Foreign References:
| WO2011130354A1 | ||||
| WO2012088006A1 |
Other References:
D.Lipovsek,Adnectins: engineered target-binding protein therapeutics,Protein Engineering, Design & Selection,2011年,Vo.24,p.3-9
Stuart L. Emanuel, et al.,A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor,mAbs,2011年,Vol.3,p.38-48
Stuart L. Emanuel, et al.,A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor,mAbs,2011年,Vol.3,p.38-48
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Hiroshi Yamazaki
Kenji Tomita