Title:
抗プリオン活性を有する分子のスクリーニングキットおよび抗プリオン活性を有する分子のスクリーニング方法およびスクリーニングされた分子
Document Type and Number:
Japanese Patent JP4529030
Kind Code:
B2
Abstract:
A kit used to screen agents for antiprion activity comprising a yeast (A) having the (PSI+) phenotype and an antibiogram, is new. Independent claims are also included for: (1) method of screening compounds for antiprion activity comprising culturing a lawn of (A) in vitro, applying test compounds by the antibiogram method, incubation for 2-4 days at 20-25 degreesC and analysis of the coloration of cell colonies; and (2) antiprion agents of formula (I). R' = hydrogen, amino or NHR2; R2 = 1-10C alkyl or alkylaminoalkyl; X = fluoro, chloro, bromo, iodo, trifluoromethyl, methylthio, methoxy, hydroxy, nitro, acetyl, aminocarbonyl, carboxy or COOR3; R3 = 1-4C alkyl; p and n = 0-2; and q = 0 or 1.
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Inventors:
Blondel marc
Bach Stefan
Curan christophe
Talalek Nicola
Vierphone Jean Michel
Mette Yvette
Bach Stefan
Curan christophe
Talalek Nicola
Vierphone Jean Michel
Mette Yvette
Application Number:
JP2005501302A
Publication Date:
August 25, 2010
Filing Date:
October 20, 2003
Export Citation:
Assignee:
Saintur Nacional de la Rushche Shandifique
Universite Victor Segalen
Universites de Poitiers
Universite Victor Segalen
Universites de Poitiers
International Classes:
C12Q1/02; A61K31/435; A61K31/554; A61P25/28; C07D221/12; C07D281/16; C12N1/19; C12N15/09; C12R1/865
Domestic Patent References:
| JP262826A |
Foreign References:
| EP0565491A1 |
Other References:
Biosci. Biotechnol. Biochem., vol. 65, pages 2472-2481 (2001)
Proc. Natl. Acad. Sci., USA, vol. 98, pages 9836-9841 (2001)
Nat. Biotechnol., vol. 21, pages 1075-1081 (2003)
Biothechnol. J., vol. 1, pages 58-67 (2006)
Proc. Natl. Acad. Sci., USA, vol. 98, pages 9836-9841 (2001)
Nat. Biotechnol., vol. 21, pages 1075-1081 (2003)
Biothechnol. J., vol. 1, pages 58-67 (2006)
Attorney, Agent or Firm:
Norihiko Hibi
Einosuke Kishimoto
Akira Watanabe
Kiyosue Yasuko
Einosuke Kishimoto
Akira Watanabe
Kiyosue Yasuko