脂質代謝改善物質のスクリーニング方法

Title:

脂質代謝改善物質のスクリーニング方法

Document Type and Number:

Japanese Patent JP4016280

Kind Code:

B2

Abstract:

It is intended to provide a method of screening a drug for improving lipid metabolism and/or a drug for improving insulin resistance without showing any side effects such as TG synthesis acceleration. An LXR transcription and conjugation factor clone 6 is identified by the yeast two-hybrid system and it is found out that this factor regulates the transcription of ABCA1 and/or SREBP1c playing important roles in lipid metabolism and sugar metabolism. Based on this finding, a screening system for a drug for improving lipid metabolism and/or improving insulin resistance, which regulates the activity or expression of the clone 6 or interaction thereof with LXR, etc. without showing any side effects such as TG synthesis acceleration, is constructed.

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Inventors:

Nishijima Tomomi
Yasushi Inoki
Ida Motoko
Atsushi Ogino
Hideki Endo

Application Number:

JP2004013728A

Publication Date:

December 05, 2007

Filing Date:

January 21, 2004

Export Citation:

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Assignee:

Astellas Pharma Inc.

International Classes:

C12Q1/02; G01N33/50; A61K45/00; A61P3/06; A61P3/10; C12N5/00; C12N5/10; C12N15/09; G01N33/15; G01N33/53; G01N33/566

Foreign References:

US20030228607

Other References:

DNA Research (1998), 5(1), 31-39

Attorney, Agent or Firm:

Morita Taku
Emiko Yano

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