SCREENING METHOD FOR MORPHOGENESIS INDUCTIVE PROTEIN

Japanese Patent JP2004069670

A

To provide a screening method for a compound which brings a change to a morphogenesis inductive protein (morphogen) level produced by a tissue of an organ, when it is dosed with the compound.

This is a method for screening a candidate compound, capable of controlling a locally or systemically effective amount or level of the morphogen in a living matter. This method is also capable of increasing or decreasing production of the morphogen in vivo, thereby is capable of modifying pathological condition, and is capable of using for identifying a hopeful compound for a medicine for human beings. After that, the candidate compound can be used for controlling effective concentration of the morphogen in medical treatment.

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SMART JOHN E (US)
OPPERMANN HERMANN (US)
OZKAYNAK ENGIN (US)
KUBERASAMPATH THANGAVEL (US)
RUEGER DAVID C (US)
PANG ROY H L (US)
COHEN CHARLES M (US)

JP2003014941A

March 04, 2004

January 23, 2003

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CURIS INC (US)

C07K14/495; C07K14/51; C07K14/52; C07K14/625; C07K16/00; C07K16/22; G01N33/50; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; G01N33/68; G01N33/74; A61K38/00; (IPC1-7): G01N33/50; C12N15/09; C12Q1/68; G01N33/15; G01N33/53; G01N33/566

Kiyoshi Fujino
Kyoko Yoshimi
Kiyonori Fujino

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