Title:
TORの活性を調節する化合物のスクリーニングおよび医薬的使用
Document Type and Number:
Japanese Patent JP2005505306
Kind Code:
A
Abstract:
Methods for screening for potential modulators of mammalian target of rapamycin (mTOR) are provided based on detecting cellular ATP levels. Also provided are compositions useful in treating diseases or conditions dependent on mTOR signaling, including cancer, rheumatoid arthritis, restinosis and transplant rejection.
Inventors:
Patrick Bryan Dennis
Anya Yesche
Sarah cozma
Masao Saito
George Thomas
Anya Yesche
Sarah cozma
Masao Saito
George Thomas
Application Number:
JP2003536750A
Publication Date:
February 24, 2005
Filing Date:
October 11, 2002
Export Citation:
Assignee:
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
International Classes:
G01N33/50; A61K31/36; A61K31/44; A61K31/70; A61K45/00; A61P9/00; A61P29/00; A61P35/00; A61P37/06; C12Q1/02; C12Q1/48; C12Q1/66; G01N33/15; G01N33/573; G01N33/574; (IPC1-7): C12Q1/66; A61K45/00; A61P9/00; A61P29/00; A61P35/00; A61P37/06; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima