Title:
スタチン薬物の組合せのスクリーニング方法および選択方法
Document Type and Number:
Japanese Patent JP2005512516
Kind Code:
A
Abstract:
A method for screening statins in their open acid form to determine the susceptibility of each tested statin to metabolic glucuronidation is provided. Also provided is a method for determining if a non-statin pharmaceutical drug co-administered with a statin that is susceptible to metabolic glucuronidation in its open acid form, will inhibit the glucuronidation of the statin and thereby increase the risk of an adverse drug interaction.
Inventors:
Plou Exari Thanonto, Tomayants
Application Number:
JP2003530212A
Publication Date:
May 12, 2005
Filing Date:
September 20, 2002
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K31/19; A61K31/197; A61K31/366; A61K31/40; A61K31/404; A61K31/47; A61K31/505; A61K45/00; A61P3/06; C12Q1/48; G01N33/15; G01N33/50; (IPC1-7): C12Q1/48; A61K31/197; A61K31/366; A61K31/40; A61K31/404; A61K31/47; A61K31/505; A61K45/00; A61P3/06; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura