Title:
SEFUAROSUHORINNO SANSORUIENKAGOBUTSUNOSEIZO
Document Type and Number:
Japanese Patent JPS5141382
Kind Code:
A
Abstract:
In accordance with this invention, it has been found that the oxygen analog of 7-aminocephalosporanic acid and biologically active derivatives thereof can be formed from esters of 7-aminocephalosporanic acid. Esters of 7-oxocephalosporanic acid can be formed by diazotization of an ester of 7-aminocephalosporanic acid and contact of the diazo compound so formed with a hypohalous acid and a base in a water miscible organic solvent. Oxygen analogs of 7-aminocephalosporins isolated as esters are then formed by reducing the aforesaid ester to the corresponding 7 beta -hydroxy-cephalosporanate and then forming the desired analog by introduction of a side chain via hydroxyl group modification. Oxygen analogs of 7-aminocephalosporins are then formed by regeneration of the acid via protective group removal.
Inventors:
JON SHII SHIIHAN
YAN SETSUKU RO
YAN SETSUKU RO
Application Number:
JP9300375A
Publication Date:
April 07, 1976
Filing Date:
July 30, 1975
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY
International Classes:
C07D501/00; (IPC1-7): C07D501/00; C07D501/04