Title:
自己安定化リンカー結合体
Document Type and Number:
Japanese Patent JP7014856
Kind Code:
B2
Abstract:
The present invention provides Ligand-Drug Conjugates, Drug-Linkers, Linkers, and Ligand-Linker Conjugates comprising a self-stabilizing linker assembly component.
Inventors:
Robert Lion
Svetlana Dronina
Timothy Bobby
Svetlana Dronina
Timothy Bobby
Application Number:
JP2020089453A
Publication Date:
February 01, 2022
Filing Date:
May 22, 2020
Export Citation:
Assignee:
Siegen Incorporated
International Classes:
A61K47/54; A61K39/395; A61K45/00; A61K47/65; A61K47/68; A61P35/00
Domestic Patent References:
| JP6423340B2 | ||||
| JP6228091A | ||||
| JP2009531325A |
Foreign References:
| US20100104589 |
Other References:
AJAJ, K. A. et al.,Development of Protein-Binding Bifunctional Linkers for a new Generation of Dual-Acting Prodrugs,Bioconjugate Chemistry,2009年,Vol.20,Pages 390-396
ALLEY, S. C. et al.,Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates,Bioconjugate Chemistry,2008年,Vol.19,Pages 759-765
WALKER, M. A. et al.,The Mitsunobu Reaction: A Novel Method for the Synthesis of Bifunctional Maleimide Linkers,Tetrahedron Letters,1994年,Vol.35, No.5,Pages 665-668
ALLEY, S. C. et al.,Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates,Bioconjugate Chemistry,2008年,Vol.19,Pages 759-765
WALKER, M. A. et al.,The Mitsunobu Reaction: A Novel Method for the Synthesis of Bifunctional Maleimide Linkers,Tetrahedron Letters,1994年,Vol.35, No.5,Pages 665-668
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
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