Title:
SEPARATION OF OPTICAL ISOMER
Document Type and Number:
Japanese Patent JP3130396
Kind Code:
B2
Abstract:
PURPOSE: To enable large-scale supply of an industrially useful high-purity optical isomer of a piperazine derivative by using an optically active tartaric acid derivative available as a low-cost host compound.
CONSTITUTION: A clathrate compound is formed from a racemic mixture of a piperazine derivative of formula I (R is H, an alkyl, acetyl, trifluoroacetyl or benzoyl; R1 is an alkyl or a halogen) and an optically active tartaric acid derivative, e.g. a compound of formula II [R2 and R3 are each H, methyl, ethyl or phenyl; Ar is phenyl, formula III or formula IV (X is methyl or a halogen)] or formula V [(n) is 1 to 6], and one of the optical isomers of formula I is separated from the clathrate compound. The mixture ratio of the optically active tartaric acid derivative to the piperazine derivative is suitably 1:0.5 to 1:8 on mole base and preferably within a range of 1:0.5 to 1:4 from the view point of, e.g. the crystallization ratio of the clathrate compound and the optical purity of the isolated piperazine derivative.
Inventors:
Kazuyoshi Nishikawa
Chisato Takeuchi
Chisato Takeuchi
Application Number:
JP34609492A
Publication Date:
January 31, 2001
Filing Date:
December 25, 1992
Export Citation:
Assignee:
Daicel Chemical Industry Co., Ltd.
International Classes:
C07B57/00; C07D241/04; C07D317/12; C07D317/72; (IPC1-7): C07D241/04; C07B57/00
Domestic Patent References:
| JP1149775A | ||||
| JP3279375A | ||||
| JP466550A |
Other References:
Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ；（１９８８）（Ｎｏ．３）ｐ５１３−５１６
Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ；ｖｏｌ．２（Ｎｏ．１０）ｐ９８３−９８６（１９９１）
Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ；ｖｏｌ．２（Ｎｏ．１０）ｐ９８３−９８６（１９９１）
Attorney, Agent or Firm:
Kaoru Furuya (3 outside)