Title:
SEX STEROID ACTIVITY INHIBITOR
Document Type and Number:
Japanese Patent JP2002060384
Kind Code:
A
Abstract:
To obtain a compound useful for treating breast cancer or other diseases promoted by their exacerbation due to the activation of sex steroid receptor, and to provide a medicament composition containing the above compound.
This compound has a general structure (A); wherein R1 and R2 are each a straight-chain or branched chain alkylene, phenylene, or the like; B is O, S, or the like; L is a moiety forming together with G a heterocyclic ring having at least one nitrogen atom, a lower alkyl, or the like; G is a moiety forming together with L a heterocyclic ring having at least one nitrogen atom, a lower alkyl, or the like; Z is a lower alkylene, O, S, or the like; R3 and R10 are each H, OH, or the like; and R6 is H, a lower alkyl, or the like. The compound can be used in medicament compositions either having anti-estrogenic activity or for inhibiting estrogen synthesis.
Inventors:
LABRIE FERNAND
MERAND YVES
Application Number:
JP2001207820A
Publication Date:
February 26, 2002
Filing Date:
December 01, 1992
International Classes:
A61K31/10; A61K31/135; A61K31/138; A61K31/165; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/435; A61K31/445; A61K31/4453; C07D295/08; A61K31/452; A61K31/4523; A61K31/453; A61K31/4535; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/535; A61K31/5375; A61K31/565; A61K31/57; A61P5/28; A61P5/32; A61P15/16; A61P17/08; A61P17/14; A61P35/00; C07C215/64; C07C217/18; C07C235/34; C07C235/40; C07C317/10; C07C317/18; C07D209/08; C07D209/12; C07D215/06; C07D215/14; C07D215/20; C07D217/04; C07D217/16; C07D235/18; C07D295/084; C07D295/092; C07D295/096; C07D295/185; C07D311/02; C07D311/04; C07D311/60; C07D335/06; C07D335/08; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D413/12; C07J1/00; C07J17/00; C07J21/00; C07J41/00; C07J51/00; C07J53/00; C07J71/00; (IPC1-7): C07D217/16; A61K31/4025; A61K31/4453; A61K31/472; A61K31/4725; A61P5/28; A61P5/32; A61P15/16; A61P17/08; A61P17/14; A61P35/00; C07C317/18; C07D295/08; C07D335/06
Attorney, Agent or Firm:
Fukami Hisaro (3 outside)
