Title:
短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
Document Type and Number:
Japanese Patent JP7330893
Kind Code:
B2
Abstract:
Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.
Inventors:
Jian Liu
Changje Wang
Pohon, Shay
Young May Shu
Changje Wang
Pohon, Shay
Young May Shu
Application Number:
JP2019549419A
Publication Date:
August 22, 2023
Filing Date:
March 12, 2018
Export Citation:
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
International Classes:
C08B37/10; A61K31/727; A61K38/36; A61K45/00; A61P7/02
Domestic Patent References:
| JP2016523535A |
Foreign References:
| US20130296540 | ||||
| US20120322114 | ||||
| US20090035787 | ||||
| WO2012116048A1 |
Other References:
Biochemistry,2008年,47(21),5774-5783
Proc Natl Acad Sci USA,2012年,Vol.109, No.14,p.5265-5270
Science,2011年,Vol.334,p.498-501
The Journal of Biological Chemistry,2010年,Vol.285, No.44,p.34240-34249
Nat. Chem. Biol.,2008年,4(3),200-202
Chem, Eur. J., ,2001年,7(22),4821-4834
Proc Natl Acad Sci USA,2012年,Vol.109, No.14,p.5265-5270
Science,2011年,Vol.334,p.498-501
The Journal of Biological Chemistry,2010年,Vol.285, No.44,p.34240-34249
Nat. Chem. Biol.,2008年,4(3),200-202
Chem, Eur. J., ,2001年,7(22),4821-4834
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation
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