Title:
短鎖干渉RNA遺伝子治療
Document Type and Number:
Japanese Patent JP2006515993
Kind Code:
A
Abstract:
Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.
Inventors:
Chang, Lang-Gee
Ho, Jin
Ho, Jin
Application Number:
JP2006501025A
Publication Date:
June 15, 2006
Filing Date:
January 15, 2004
Export Citation:
Assignee:
University of Florida
International Classes:
C12N15/09; A61K31/711; A61K35/76; A61K48/00; A61P19/02; A61P29/00; A61P31/12; A61P31/18; A61P35/00; C12N7/00; C12N15/11; C12N15/113
Attorney, Agent or Firm:
Mamoru Ushiki
Shimizu Sakaematsu
Masayoshi Yoshida
Kuniaki Toyama
Shimizu Sakaematsu
Masayoshi Yoshida
Kuniaki Toyama