Title:
結合能を有するシアリル・ルイスX類似物
Document Type and Number:
Japanese Patent JP4262480
Kind Code:
B2
Abstract:
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLeX compositions. In particular, the disclosed SLeX compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLeX compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl LeX, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.
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Inventors:
Ranganasan, Ramachandra
Lamarine gum, Condaredia
Pilai, Radha Krishna
Marinelli, Edmund Earl.
Svenson, Rolf
Lamarine gum, Condaredia
Pilai, Radha Krishna
Marinelli, Edmund Earl.
Svenson, Rolf
Application Number:
JP2002563162A
Publication Date:
May 13, 2009
Filing Date:
November 29, 2001
Export Citation:
Assignee:
BRACCO INTERNATIONALB.V.
International Classes:
C07H15/00; A61K31/192; A61K31/337; A61K31/546; A61K31/555; A61K31/7028; A61K31/7036; A61K38/17; A61K45/00; A61K47/36; A61K47/44; A61K47/48; A61K49/00; A61K51/00; A61P3/04; A61P3/10; A61P9/10; A61P29/00; A61P31/00; A61P35/00; C07D257/02; C07H7/02; C07H15/04; C07H15/18; C07K5/083; C07K7/02
Domestic Patent References:
| JP7109301A | ||||
| JP7503254A | ||||
| JP10502931A |
Attorney, Agent or Firm:
Kameda Tetsuaki