Title:
シラン含有水分硬化性組織シーラント
Document Type and Number:
Japanese Patent JP6688610
Kind Code:
B2
Abstract:
A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.
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Inventors:
Crower dotty
Dobbins Despina
Cladakis Stephanie
Dobbins Despina
Cladakis Stephanie
Application Number:
JP2015546547A
Publication Date:
April 28, 2020
Filing Date:
December 03, 2013
Export Citation:
Assignee:
Cohera Medical Incorporated
International Classes:
A61L15/26; A61L15/64; A61L17/06; A61L24/04; A61L31/14; C08G18/06; C08G18/71; C08L75/04
Domestic Patent References:
| JP363061A |
Foreign References:
| US20120184926 | ||||
| US20080060550 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto