Title:
SILK BIOMATERIAL AND METHOD OF USE THEREOF
Document Type and Number:
Japanese Patent JP2011019923
Kind Code:
A
Abstract:
To provide an all-aqueous process and composition for production of silk biomaterials (e.g., fibers, films, foams, and mats).
In the process, at least one biocompatible polymer, such as polyethylene oxide (PEO) (a well-documented biocompatible material), has been blended with the silk protein prior to processing (e.g., electrospinning). This step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
Inventors:
KAPLAN DAVID L
JIN HYOUNG-JOON
RUTLEDGE GREGORY
FRIDRIKH SERGEY
JIN HYOUNG-JOON
RUTLEDGE GREGORY
FRIDRIKH SERGEY
Application Number:
JP2010183530A
Publication Date:
February 03, 2011
Filing Date:
August 19, 2010
Export Citation:
Assignee:
UNIV TUFTS
MASSACHUSETTS INST TECHNOLOGY
MASSACHUSETTS INST TECHNOLOGY
International Classes:
A61L29/00; A61L15/16; A61L27/22; A61L27/36; A61L27/44; A61L27/48; B32B27/06; C07K14/435; C08H1/00; C08L89/00; C12N5/07; C12N5/071; D01D5/00; D01F4/02; D01F6/88; D02G3/04; D06M13/17; D06M15/00; D06M15/03; D06M15/11; C08J
Domestic Patent References:
| JPH03502053A | 1991-05-16 | |||
| JPH11228837A | 1999-08-24 | |||
| JPH03502053A | 1991-05-16 | |||
| JP2000273264A | 2000-10-03 | |||
| JPS63190604A | 1988-08-08 |
Foreign References:
| WO2001019287A1 | 2001-03-22 |
Other References:
JPN6012050201; 日本蚕糸学雑誌 Ｖｏｌ．６６， Ｎｏ．２, 1997, ｐ．１３８-１４０
JPN6012050203; Ｊｏｕｒｎａｌ ｏｆ Ａｐｐｌｉｅｄ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ Ｖｏｌ．４５, 1992, ｐ．１９３７-１９４３
JPN6012050203; Ｊｏｕｒｎａｌ ｏｆ Ａｐｐｌｉｅｄ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ Ｖｏｌ．４５, 1992, ｐ．１９３７-１９４３
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi