SILK BIOMATERIAL AND METHOD OF USE THEREOF

Title:

SILK BIOMATERIAL AND METHOD OF USE THEREOF

Document Type and Number:

Japanese Patent JP2014138877

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats, the process which avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials, and, moreover, avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.SOLUTION: At least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with silk protein prior to processing e.g., electrospinning.

Inventors:

KAPLAN DAVID L
JIN HYOUNG-JOON
RUTLEDGE GREGORY
FRIDRIKH SERGEY

Application Number:

JP2014043805A

Publication Date:

July 31, 2014

Filing Date:

March 06, 2014

Export Citation:

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Assignee:

UNIV TUFTS
MASSACHUSETTS INST TECHNOLOGY

International Classes:

A61L27/00; A61L27/22; A61L27/36; A61L27/44; A61L27/48; B32B27/06; C07K14/435; C08H1/00; C08L89/00; C12N5/07; C12N5/071; D01D5/00; D01F4/02; D01F6/88; D02G3/04; D04H1/728; D06M13/17; D06M15/00; D06M15/03; D06M15/11; C08J

Foreign References:

US6110590A	2000-08-29
US6110590A	2000-08-29

Other References:

JPN6009054648; Ｊ．　Ｂｉｏｍａｔｅｒ．　Ｓｃｉ．　Ｐｏｌｙｍｅｒ　ＥｄｎＶｏｌ．１２，　Ｎｏ．９, 2001, ｐ．９７９-９９３
JPN6015011245; 大郷耕輔　他: 'エレクトロスピニング法による家蚕絹及び野蚕絹フィブロインのナノ繊維の作成及びキャラクタリゼーション' 高分子学会予稿集５１巻, 200205, ｐ．１１０９
JPN6009054648; Ｊ．　Ｂｉｏｍａｔｅｒ．　Ｓｃｉ．　Ｐｏｌｙｍｅｒ　ＥｄｎＶｏｌ．１２，　Ｎｏ．９, 2001, ｐ．９７９-９９３
JPN6015011245; 大郷耕輔　他: 'エレクトロスピニング法による家蚕絹及び野蚕絹フィブロインのナノ繊維の作成及びキャラクタリゼーション' 高分子学会予稿集５１巻, 200205, ｐ．１１０９

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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