Title:
SINGLE AMINO ACID MUTATION PROTEIN OF HISTONE H4, ITS MUTANT CELL AND THEIR USE
Document Type and Number:
Japanese Patent JP3868987
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new yeast cell line given a novel characteristics by introducing single amino acid mutation into histone H3 or H4 without directly engineering a gene encoded by a genome DNA and its transcription product, and its use.
SOLUTION: Disclosed are a mutant yeast cell expressing a mutant histone H3 protein or histone H4 protein in which a specific amino acid residue is substituted by alanine residue, those mutant histone proteins, polynucleotides encoding these mutant proteins, and a method for using these cells, proteins and polynucleotides.
Inventors:
Takashi Umehara
Kazuko Matsubara
Horikoshi Masami
Kazuko Matsubara
Horikoshi Masami
Application Number:
JP2005372856A
Publication Date:
January 17, 2007
Filing Date:
December 26, 2005
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C12N15/09; C07K14/39; C12N1/19; C12Q1/02
Domestic Patent References:
| JP3773460B2 | ||||
| JP3780295B2 | ||||
| JP2006129872A |
Other References:
Mol. Cell. Biol., 1996, Vol.16, p.1017-1026
The EMBO Journal, 1997, Vol.16, p.2493-2506
Genes Dev., 1995, Vol.9, p.2770-2779
The Journal of Biological Chemistry, 1991, Vol.266, p.6489-6498
The Journal of Biological Chemistry, 1993, Vol.268, p.1118-1124
Mol. Cell. Biol., 1990, Vol.10, p.4932-4934
The EMBO Journal, 1997, Vol.16, p.2493-2506
Genes Dev., 1995, Vol.9, p.2770-2779
The Journal of Biological Chemistry, 1991, Vol.266, p.6489-6498
The Journal of Biological Chemistry, 1993, Vol.268, p.1118-1124
Mol. Cell. Biol., 1990, Vol.10, p.4932-4934
Attorney, Agent or Firm:
Toshio Nishizawa
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