Title:
サーチュインモジュレーターであるN-フェニルベンズアミド誘導体
Document Type and Number:
Japanese Patent JP2008535790
Kind Code:
A
Abstract:
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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Inventors:
Milbern, michael
Milne, Jill
Bee miss, jean
Nunes, Joseph Jay.
Xie, Roger
Nomington, Carl Dee.
Boo, Chi Bee.
Milne, Jill
Bee miss, jean
Nunes, Joseph Jay.
Xie, Roger
Nomington, Carl Dee.
Boo, Chi Bee.
Application Number:
JP2007558290A
Publication Date:
September 04, 2008
Filing Date:
March 03, 2006
Export Citation:
Assignee:
Sir Tris Pharmaceuticals, Inc.
International Classes:
C07C233/81; A01N1/02; A61K31/122; A61K31/196; A61K31/205; A61K31/235; A61K31/341; A61K31/355; A61K31/381; A61K31/385; A61K31/403; A61K31/4184; A61K31/423; A61K31/428; A61K31/429; A61K31/437; A61K31/455; A61K31/475; A61K31/498; A61K31/51; A61K31/525; A61K31/536; A61K31/5375; A61K31/551; A61K31/573; A61K33/04; A61K33/24; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P15/08; A61P19/02; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C235/56; C07C235/64; C07C237/42; C07D209/92; C07D235/14; C07D241/42; C07D243/08; C07D263/56; C07D265/14; C07D265/30; C07D277/66; C07D307/24; C07D333/38; C07D471/04; C07D498/04; C07D513/04
Foreign References:
| WO2004046122A2 | 2004-06-03 | |||
| WO2003011219A2 | 2003-02-13 | |||
| US3164603A | 1965-01-05 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita