Title:
標的リガンドをエンドソーム分解性成分と組み合わせることによる核酸の部位特異的送達
Document Type and Number:
Japanese Patent JP5788312
Kind Code:
B2
Abstract:
The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.
Inventors:
Manoharan, Mutier
Rajiv, Callant Hottat Hill Gee
Butler, david
Jayaraman, Muthusami
Narayanan Nile, Jayapura Kay
Shigeo Matsuda
Rajiv, Callant Hottat Hill Gee
Butler, david
Jayaraman, Muthusami
Narayanan Nile, Jayapura Kay
Shigeo Matsuda
Application Number:
JP2011504224A
Publication Date:
September 30, 2015
Filing Date:
April 10, 2009
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
International Classes:
A61K31/7088; A61K31/7105; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61K39/395; A61K47/08; A61K47/12; A61K47/14; A61K47/22; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K47/48; A61K48/00; A61L27/00; A61L29/00; A61L31/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P33/00; A61P33/06; A61P35/00; A61P35/02; A61P37/00; C12N15/11; C12N15/87
Domestic Patent References:
| JP2008501319A |
Foreign References:
| WO2008022309A1 |
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma