Title:
メチルトランスフェラーゼ(HMTASE)の部位特異的阻害剤及びその製剤方法
Document Type and Number:
Japanese Patent JP2009542626
Kind Code:
A
Abstract:
The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is —OCH3 or —OH, R2 and R2 is —OH or —OAc; a process of isolating compound of structural formula Ia, where R1 and R1 is —OCH3, R2 and R2 is —OH; a process of preparation of compound of structural formula Ib, where R1 and R1 is —OCH3, R2 and R2 is —OAc; a process of preparation of compound of structural formula Ic, where R1 and R1 is —OH, R2 and R2 is —OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof.
Inventors:
Kundu, Tapas, Kumar
Vickle, Ruth Rosa, Servi, Barasa
Anna Valap, Hari, Kishore
Kempegowda, Manteling
Vickle, Ruth Rosa, Servi, Barasa
Anna Valap, Hari, Kishore
Kempegowda, Manteling
Application Number:
JP2009517615A
Publication Date:
December 03, 2009
Filing Date:
June 26, 2007
Export Citation:
Assignee:
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
International Classes:
C07C65/105; A61K31/194; A61P35/00; A61P43/00; C07C51/09; C07C67/08; C07C69/94; A61K31/366; C07D493/06
Domestic Patent References:
| JPS63130589A | 1988-06-02 |
Foreign References:
| US5066671A | 1991-11-19 |
Other References:
JPN6011064660; Ｊｏｕｒｎａｌ ｏｆ Ａｇｒｉｃｕｌｔｕｒａｌ ａｎｄ Ｆｏｏｄ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５３, 2005, ｐ．７７１５-７７２０
JPN6011064661; Ｓｅｐａｒａｔｉｏｎ ａｎｄ Ｐｕｒｉｆｉｃａｔｉｏｎ Ｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．４１, 2004, ｐ．４９-５５
JPN6011064662; Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６，Ｎｏ．５, 1992, ｐ．７６６-７６８
JPN6012029181; Ｃａｎｃｅｒ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３６，Ｎｏ．２, 1999, ｐ．２１５-２２１
JPN6011064662; Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６， Ｎｏ．５, 1992, ｐ．７６６-７６８
JPN6011064660; Ｊｏｕｒｎａｌ ｏｆ Ａｇｒｉｃｕｌｔｕｒａｌ ａｎｄ Ｆｏｏｄ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５３, 2005, ｐ．７７１５-７７２０
JPN6011064661; Ｓｅｐａｒａｔｉｏｎ ａｎｄ Ｐｕｒｉｆｉｃａｔｉｏｎ Ｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．４１, 2004, ｐ．４９-５５
JPN6011064661; Ｓｅｐａｒａｔｉｏｎ ａｎｄ Ｐｕｒｉｆｉｃａｔｉｏｎ Ｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．４１, 2004, ｐ．４９-５５
JPN6011064662; Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６，Ｎｏ．５, 1992, ｐ．７６６-７６８
JPN6012029181; Ｃａｎｃｅｒ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３６，Ｎｏ．２, 1999, ｐ．２１５-２２１
JPN6011064662; Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６， Ｎｏ．５, 1992, ｐ．７６６-７６８
JPN6011064660; Ｊｏｕｒｎａｌ ｏｆ Ａｇｒｉｃｕｌｔｕｒａｌ ａｎｄ Ｆｏｏｄ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５３, 2005, ｐ．７７１５-７７２０
JPN6011064661; Ｓｅｐａｒａｔｉｏｎ ａｎｄ Ｐｕｒｉｆｉｃａｔｉｏｎ Ｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．４１, 2004, ｐ．４９-５５
Attorney, Agent or Firm:
Hiroshi Arafune
Yoshio Arafune
Yoshio Arafune