Title:
固体キラルジルコニウム触媒及びそれを用いたアルドール反応物又は環化体化合物の合成方法
Document Type and Number:
Japanese Patent JP4696274
Kind Code:
B2
Abstract:
To provide a solid chiral zirconium catalyst which is capable of effecting long-term preservation and which is suitable for catalystic asymmetry aldol reaction and catalytic asymmetry hetero Diels-Alder reaction and to provide a synthetic method of an aldol reaction product or cyclized compound using the same.
The synthetic method uses a powder zirconium catalyst obtained by reacting a binaphthol or its enantiomer with a zirconium compound in an organic solvent, adding a nonpolar solvent to the reaction mixture and isolating the resulting solid precipitation.
COPYRIGHT: (C)2008,JPO&INPIT
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Inventors:
Osamu Kobayashi
Kazuki Seki
Masaharu Ueno
Kazuki Seki
Masaharu Ueno
Application Number:
JP2007051428A
Publication Date:
June 08, 2011
Filing Date:
March 01, 2007
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
B01J31/22; B01J37/03; C07B53/00; C07C67/347; C07C69/675; C07C69/732; C07C327/22; C07D309/32; C07B61/00
Domestic Patent References:
| JP2003299962A | ||||
| JP2002356454A | ||||
| JP2006022046A |
Foreign References:
| WO2003076072A1 |
Other References:
Kowichiro Saruhashi et al.,"Remarkably Stable Chiral Zirconium Complexes for Asymmetric Mannich-Type Reactions",Journal of the American Chemical Society,2006年,Vol.128, No.34,p.11232-11235
山下恭弘 他,"新規キラルジルコニウム触媒を用いる不斉アルドール反応",日本化学会第79春季年会(2001)講演予稿集II,2001年,p.1106左上
小林修 他,"キラルジルコニウム触媒を用いる不斉ヘテロDiels-Alder反応",日本化学会第79春季年会(2001)講演予稿集II,2001年,p.1106右上
齋藤奨 他,"キラルジルコニウム触媒を用いるα-ベンジルオキシ-β-ヒドロキシエステルの高立体選択的合成反応の開発",日本化学会第84春季年会(2004)講演予稿集II,2004年,p.1217左上
Shu Kobayashi et al.,"An air-stable, storable chiral zirconium catalyst for asymmetric aldol reactions",Chemical Communications,2003年,No.16,p.2016-2017
山下恭弘 他,"新規キラルジルコニウム触媒を用いる不斉アルドール反応",日本化学会第79春季年会(2001)講演予稿集II,2001年,p.1106左上
小林修 他,"キラルジルコニウム触媒を用いる不斉ヘテロDiels-Alder反応",日本化学会第79春季年会(2001)講演予稿集II,2001年,p.1106右上
齋藤奨 他,"キラルジルコニウム触媒を用いるα-ベンジルオキシ-β-ヒドロキシエステルの高立体選択的合成反応の開発",日本化学会第84春季年会(2004)講演予稿集II,2004年,p.1217左上
Shu Kobayashi et al.,"An air-stable, storable chiral zirconium catalyst for asymmetric aldol reactions",Chemical Communications,2003年,No.16,p.2016-2017
Attorney, Agent or Firm:
Kenichiro Akao
Akira Shimoda
Akira Shimoda