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Title:
光安定性を向上させた固形状組成物
Document Type and Number:
Japanese Patent JP7285040
Kind Code:
B2
Abstract:
To provide a solid composition that contains dextromethorphan hydrobromide or dihydrocodeine phosphate, and promethazine methylenedisalicylate, in which the solid composition is hardly colored when irradiated with light.SOLUTION: A solid composition has a coating layer containing a light stabilization material and a polymer, and contains dextromethorphan hydrobromide or dihydrocodeine phosphate, and promethazine methylenedisalicylate, wherein, when irradiated with light of 1,200,000 lux hr, the solid composition has a color difference ΔE of 12 or less.SELECTED DRAWING: None

Inventors:
Mitsuto Izumi
Hiroshi Murasato
Satoru Yoshimoto
Muguruma Jiagong
Tomoatsu Toyoda
Yohei Shimada
Yumi Nakai
Fumie Sumura
Application Number:
JP2019107421A
Publication Date:
June 01, 2023
Filing Date:
June 07, 2019
Export Citation:
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Assignee:
Shionogi Healthcare Co., Ltd.
International Classes:
A61K31/5415; A61K9/32; A61K31/167; A61K31/192; A61K31/485; A61K31/522; A61K47/02; A61K47/38; A61P29/00; A61P43/00; B65D81/30
Domestic Patent References:
JP2007302578A
JP2008100924A
JP2013506642A
JP2004300138A
JP2001253826A
JP2005519923A
Other References:
Acta Poloniae Parmaceutica-Drug Research,2002年,Vol.59, No.1,pp.45-51
Langmuir,2014年,Vol.30,pp.14612-14620
第十六改正日本薬局方,p.1220,2011年
第十六改正日本薬局方,2011年,pp.705-706
Japanese Journal of Pharmaceutical Health Care and Sciences,2009年,Vol.35, No.6,pp.395-402
Attorney, Agent or Firm:
Kenichi Sugita