Title:
固形医薬製剤
Document Type and Number:
Japanese Patent JP4965261
Kind Code:
B2
Abstract:
To provide a sustained-release solid pharmaceutical preparation having a quick-release part and a sustained-release part and stably having an excellent quick releasing characteristic with little pH dependency in an initial dissolution. The present invention relates to that, in a preparation containing a medical ingredient as an effective ingredient, particularly active analgesic ingredient, a sustained-release solid pharmaceutical preparation which is characterized in that it is a solid pharmaceutical form having a quick-release part and a sustained-release part and contains effective ingredient in both parts and the quick-release part contains a partly pregelatinized starch and a low substituted hydroxypropylcellulose as additives. In the preparation of the present invention, stable and quick initial dissolution behavior being independent upon pH is achieved even when some sustained-release part is contaminated in the quick-release part due to the difference in the tabletting method for multi-layered tablets. Furthermore, the preparation is practical as a preparation having a sufficient hardness in view of necessity that abrasion, breakage, crack, etc. are not generated when the tablet is coated.
Inventors:
Naoki Ishitsubo
Application Number:
JP2006539152A
Publication Date:
July 04, 2012
Filing Date:
May 17, 2005
Export Citation:
Assignee:
Nippon Organ Pharmaceutical Co., Ltd.
International Classes:
A61K47/36; A61K9/24; A61K9/30; A61K31/135; A61K47/02; A61K47/38; A61P25/04
Domestic Patent References:
| JP8020537A | ||||
| JP2000351732A |
Foreign References:
| WO2002087549A1 | ||||
| WO1995026753A1 | ||||
| WO2004078173A1 |
Other References:
医薬品添加物事典,1994年,第1版,51ページ
Attorney, Agent or Firm:
Ikuo Fujii